“For even when we arrived in Macedonia we had a wretched time and were troubled all around—wrangling outside and anxiety within. God, who cheers the depressed, gave us the comfort of the arrival of Titus.” (2 Corinthians 7:5-11)
The Greek word for troubled means "to press," like grapes after a harvest. That's how Paul felt. People had been trying to kill him, the churches he started were floundering, and life in general was really beating him down.
So what does Paul say we do when we are troubled outside and inside? Look to God, who cheers the depressed. How does God to this? In this case, through the arrival of Titus. Of course, God comforts us directly through His Holy Spirit. Jesus himself said,
“Come to me, all who labor and are heavy laden, and I will give you rest. Take my yoke upon you, and learn from me, for I am gentle and humble in heart, and you will find rest for your souls.” (Matthew 11:28-29)
But we can't overlook the fact that sometimes the comfort He brings finds its power through the presence of others.
After the Boston bombing marathon, a number of moving pictures showed the survivors being helped and comforted by others. The same is true after every large scale event - hurricanes, tsunamis, shootings, fertilizer plant explosions.
We don't have to go any farther than our own neighborhood. When we hear that a friend or family member died, we reflexively ask, "Who is with them right now?" Whenever there is a tragedy, we know that the presence of others is important.